Stimulation of protein kinase a activity in the rat amygdala enhances reward-related learning.

@article{Jentsch2002StimulationOP,
  title={Stimulation of protein kinase a activity in the rat amygdala enhances reward-related learning.},
  author={James David Jentsch and Peter Olausson and Eric J Nestler and Jane Rebecca Taylor},
  journal={Biological psychiatry},
  year={2002},
  volume={52 2},
  pages={111-8}
}
BACKGROUND Drug addiction in humans is associated with abnormal metabolic activity within the amygdala and heightened control of behavior by drugs and drug-related (conditioned) stimuli. Drug-induced neuroadaptations, including activation of cAMP (cyclic adenosine monophosphate)-dependent protein kinase A (PKA), within the amygdala may contribute to the synaptic plasticity and reward-related learning that underlies pathologic behavior in addicted individuals. METHODS In this study, we tested… CONTINUE READING
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