Stimulation of prodynorphin gene expression requires a functional protein kinase A.


To investigate the involvement of the cAMP/protein kinase A (PKA) second messenger system in mediating the hormonal regulation of prodynorphin expression, a normal, homologous cell transfection model was used. Ovarian granulosa cells, which express high levels of prodynorphin mRNA in response to hormonal stimulation, were obtained from the ovaries of… (More)


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