Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1 beta or phorbol ester.

@article{Stephenson1987StimulationOP,
  title={Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1 beta or phorbol ester.},
  author={Mary Stephenson and Mary B Goldring and James R Birkhead and Stephen M. Krane and Hans Jobst Rahmsdorf and Peter Angel},
  journal={Biochemical and biophysical research communications},
  year={1987},
  volume={144 2},
  pages={583-90}
}
Interleukin 1, a product predominantly of monocytes, increases the synthesis and release of procollagenase and prostaglandin E2 by mesenchymal target cells such as synovial fibroblasts and articular chondrocytes, an effect mimicked by some phorbol esters. In order to determine the mechanisms underlying these responses primary cultures of human articular chondrocytes were preincubated with recombinant human interleukin 1 beta or the phorbol ester, phorbol 12-myristate 13-acetate, in the presence… CONTINUE READING

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