Stimulation of platelet glycoprotein IIb-IIIa (alpha IIb beta 3-integrin) functional activity by a monoclonal antibody to the N-terminal region of glycoprotein IIIa.

@article{Mazurov1996StimulationOP,
  title={Stimulation of platelet glycoprotein IIb-IIIa (alpha IIb beta 3-integrin) functional activity by a monoclonal antibody to the N-terminal region of glycoprotein IIIa.},
  author={Alexey V. Mazurov and Svetlana G Khaspekova and Tatiana V. Byzova and Tikhomirov OYu and Michael C. Berndt and Bruce F Steiner and William C. Kouns},
  journal={FEBS letters},
  year={1996},
  volume={391 1-2},
  pages={84-8}
}
Platelet glycoprotein (GP) IIb-IIIa complex (alpha IIb beta 3-integrin) changes its conformation upon platelet activation that results in binding of RGD-containing ligands and expression of ligand-induced binding site (LIBS) neoepitopes. Anti-GIIb-IIIa monoclonal antibody (monAB) CRC54 bound to < or = 10% of GPIIb-IIIa on resting platelets but binding was enhanced by the occupation of GPIIb-IIIa with RGDS peptide and by platelet activation indicating that CRC54 is directed against LIBS epitope… CONTINUE READING

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