Stimulation of plasminogen activator and inhibitor in the lymphatic endothelium.

@article{Leak2000StimulationOP,
  title={Stimulation of plasminogen activator and inhibitor in the lymphatic endothelium.},
  author={Lee V. Leak and Mary Anne Saunders and Anthony A Day and Mark Howard Jones},
  journal={Microvascular research},
  year={2000},
  volume={60 3},
  pages={201-11}
}
Chromogenic assays, immunoblotting, and Northern blot hybridization methods were employed to assess the effects of various agonists on the production of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) by the lymphatic endothelium (LEC). Fibrin autography showed that plasminogen-dependent fibrinolytic activity occurred at M(r) of 110 kDa, which represents a complex of tPA with PAI-1, and 65- and 55-kDa bands corresponding to tPA and uPA, respectively. The… CONTINUE READING