Stimulation of phosphoinositide hydrolysis and inhibition of cyclic AMP formation by muscarinic agonists in developing chick heart.

@article{Orellana1985StimulationOP,
  title={Stimulation of phosphoinositide hydrolysis and inhibition of cyclic AMP formation by muscarinic agonists in developing chick heart.},
  author={Stephanie A. Orellana and J. H. U. Brown},
  journal={Biochemical pharmacology},
  year={1985},
  volume={34 8},
  pages={
          1321-4
        }
}
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24 Citations
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24 Citations

Changes in expression of a functional Gi protein in cultured rat heart cells.

Findings support the view that, although Gi is expressed, it is nonfunctional in 4-day-old cultured neonatal rat heart myocytes and acquisition of functional Gi is dependent on culture conditions and the ANG II receptor can couple to Gi in heart.

Enhanced Coupling of Neonatal Muscarinic Receptors in Rat Brain to Phosphoinositide Turnover

It is indicated that muscarinic receptors in fetal and newborn rat cerebral cortex are more efficiently coupled to stimulation of phosphoinositide turnover than in the adult.

Guanine Nucleotide‐Dependent Inositol Trisphosphate Formation in Chick Heart Cells

A saponin-permeabilized cell preparation that would allow external manipulation of the intracellular guanosine triphosphate (GTP) concentration is developed and evidence that a guanine nucleotide-binding protein is involved in the regulation of the polyphosphoinositide-specific phospholipase C in the heart is provided.

Subtype-specific Regulation of Muscarinic Receptor Expression and Function by Heterologous Receptor Activation (*)

Extended activation of β-adrenergic receptors results in an increase in mAChR number and muscarinic responsiveness in chick heart cells due to a cAMP-dependent protein kinase mediated increase in cm2 mRNA levels.

Visualization of muscarinic cholinergic receptors on chick cardiomyocytes and their involvement in phosphatidylcholine hydrolysis

Phosphatidylcholine hydrolysis induced by mACh-R stimulation may be a signal transduction pathway for mA cholinergic receptor in the cardiomyocyte, operating through inhibitory G proteins sensitive to pertussis toxin.

Pertussis Toxin‐Insensitive Phosphoinositide Hydrolysis, Membrane Depolarization, and Positive Inotropic Effect of Carbachol in Chick Atria

It is suggested that muscarinic agonist-induced PI turnover may be responsible for the membrane depolarization and positive inotropic effects of carbachol and acetylcholine, and that an increase in Na+ conductance underlies these responses.

A comparison of muscarinic acetylcholine receptors coupled to phosphatidylinositol turnover and to adenylate cyclase in guinea-pig atria and ventricles.

Carbachol-regulation of the expression of alpha i1-subunit of Gi and inositol-[1,4,5]-trisphosphate receptor in brain samples obtained from neonatal and adult rats.

  • Ashutosh Kumar Singh
  • Biology
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology
  • 1995

Muscarinic control of the hyperpolarization‐activated current (if) in rabbit sino‐atrial node myocytes.

The results indicate that the inhibitory effect of ACh on if is mediated by G‐proteins activated by muscarinic receptors, and rule against the ACh action being mediated by PDE or by phosphoinositide turnover.

Coordinate interactions of cyclic nucleotide and phospholipid metabolizing pathways in calcium-dependent cellular processes.

References

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Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism.

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Ontogenesis of physiological responsiveness and guanine nucleotide sensitivity of cardiac muscarinic receptors during chick embryonic development.

The mAChR in hearts from 4-day embryos were significantly less susceptible to regulation of receptor number by in vivo agonist treatment and required a 2-5-fold greater dose of the muscarinic agonist carbachol to achieve a decrease in receptor number equivalent to that observed in 5- or 8-day embryonic hearts.

Increase of cyclic AMP levels induced by isoproterenol in cultured and non-cultured chick embryonic hearts.

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High cyclic AMP levels in young chick embryonic hearts.

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These results are interpreted in a model in which cyclic AMP modulates the permeability of the membrane to Ca2+ and in which GTP regulates the β-adrenergic receptor and adenylate cyclase, and speculated that "indirect" muscarinic inhibition results from interference with GTP-dependent regu- lation of β- adrenergic receptors/adenylate Cyclase interaction.

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