Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.

  title={Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.},
  author={Paschal A. Oude Weernink and Patrick Schulte and Yunqian Guo and Jana Wetzel and Mutsuki Amano and Kozo Kaibuchi and S Haverland and Melanie L Voss and Martina Schmidt and Georg W. Mayr and Karl Heinz Jakobs},
  journal={The Journal of biological chemistry},
  volume={275 14},
The serine/threonine kinase Rho-kinase was recently identified as a downstream effector of the small GTPase Rho, mediating effects of Rho on the actin cytoskeleton. Also phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) has been implicated in the regulation of actin polymerization. As the synthesis of PI(4,5)P(2) has been suggested to be affected by Rho proteins, we investigated whether Rho-kinase is involved in the control of PI(4,5)P(2) levels. Overexpression of RhoA in HEK-293 cells… CONTINUE READING