Stimulation of phosphatidylinositol (PI) turnover may mediate the muscarinic suppression of the M-current in hippocampal pyramidal cells.

Abstract

The mechanism involved in the muscarinic blockade of the M-current was examined in hippocampal pyramidal cells. Muscarinic agents which are full agonists at stimulating phosphatidylinositol (PI) turnover, such as oxotremorine-M, block the M-current, while those agents which are weak agonists, such as oxotremorine, had little effect on the M-current. These… (More)

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