Stimulation of pheomelanogenesis in cultured B16 melanoma cells by 4-tertiary butylcatechol.

@article{Kawashima1985StimulationOP,
  title={Stimulation of pheomelanogenesis in cultured B16 melanoma cells by 4-tertiary butylcatechol.},
  author={Tomohiko Kawashima and Magnus M. Halldin and Kanako Fukuyama and Neal Castagnoli and Gerald A. Gellin and WilliamL. Epstein},
  journal={Biochemical pharmacology},
  year={1985},
  volume={34 19},
  pages={
          3517-21
        }
}
Intermediates of pheomelanin in tissue cultured B16 melanoma cells were analyzed by high performance liquid chromatography, and reduced glutathione (GSH), L-dopa, 2-[(L)-S-cysteinyl]-L-dopa (2-SCD) and 5-[(L)-S-cysteinyl]-L-dopa (5-SCD) were quantified. The effects of 4-tertiary butylcatechol (TBC), an antioxidant which causes skin depigmentation, on the levels of the intermediate were then examined. A concentration of 10(-4) M TBC increased the intracellular levels of GSH, 2-SCD and 5-SCD… CONTINUE READING
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