Stimulation of p21ras upon T-cell activation

@article{Downward1990StimulationOP,
  title={Stimulation of p21ras upon T-cell activation},
  author={Julian Downward and Jonathan D. Graves and Patricia H. Warne and Sydonia Rayter and Doreen A Cantrell},
  journal={Nature},
  year={1990},
  volume={346},
  pages={719-723}
}
External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C. 
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