Stimulation of ornithine decarboxylase by human cytomegalovirus.

  title={Stimulation of ornithine decarboxylase by human cytomegalovirus.},
  author={Harriet C. Isom},
  journal={The Journal of general virology},
  volume={42 2},
Human cytomegalovirus (HCMV) infection of low serum-arrested confluent whole human embryo (Flow 5000) cells markedly stimulated ornithine decarboxylase (ODC) activity. Increased ODC activity was apparent by 12 h post-infection. The capacity of HCMV to stimulate ODC was: (1) dependent upon multiplicity of infection; (2) eliminated when the virus was neutralized with specific antiserum; and (3) sensitive to ultraviolet irradiation. Virus-mediated induction, in contrast to high serum induction of… CONTINUE READING


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