Stimulation of naïve monocytes and PBMCs with coagulation proteases results in thrombin-mediated and PAR-1-dependent cytokine release and cell proliferation in PBMCs only.

@article{Nieuwenhuizen2013StimulationON,
  title={Stimulation of na{\"i}ve monocytes and PBMCs with coagulation proteases results in thrombin-mediated and PAR-1-dependent cytokine release and cell proliferation in PBMCs only.},
  author={L. C. van Nieuwenhuizen and Willem J. J. Falkenburg and Roger E. G. Schutgens and G. P. M. Roosendaal and Karin van Veghel and Douwe Hedde Biesma and Floris P. Lafeber},
  journal={Scandinavian journal of immunology},
  year={2013},
  volume={77 5},
  pages={339-49}
}
Protease-activated receptors (PARs) are stimulated by proteolytic cleavage of their extracellular domain. Coagulation proteases, such as FVIIa, the binary TF-FVIIa complex, free FXa, the ternary TF-FVIIa-FXa complex and thrombin, are able to stimulate PARs. Whereas the role of PARs on platelets is well known, their function in naïve monocytes and peripheral blood mononuclear cells (PBMCs) is largely unknown. This is of interest because PAR-mediated interactions of coagulation proteases with… CONTINUE READING

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