Stimulation of myelin gene expression in vitro and of sciatic nerve remyelination by interleukin-6 receptor-interleukin-6 chimera.

@article{Haggiag2001StimulationOM,
  title={Stimulation of myelin gene expression in vitro and of sciatic nerve remyelination by interleukin-6 receptor-interleukin-6 chimera.},
  author={Shalom Haggiag and Ping Zhang and G Slutzky and Vera Shinder and Akhilesh S Kumar and Judith Chebath and Michel Revel},
  journal={Journal of neuroscience research},
  year={2001},
  volume={64 6},
  pages={564-74}
}
Induction of myelin gene expression denotes the last stage of differentiation of myelinating glial cells. Following peripheral nerve transection, Schwann cells (SC) lose myelin gene expression and proliferate, resembling premyelinating embryonic SC (eSC). We show that a fusion protein of the soluble interleukin-6 receptor to interleukin-6 (IL6RIL6), a potent activator of the gp130 signaling receptor, is an inducer of MBP and Po gene products in rat E18 embryonic dorsal root ganglia (DRG) 3 day… CONTINUE READING

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