Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines.

@article{Xu1998StimulationOM,
  title={Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines.},
  author={Mary Jue Xu and Kohichiro Tsuji and Takeshi Ueda and Yoh-Suke Mukouyama and Takahiko Hara and Fan Chiang Yang and Yasuhiro Ebihara and Sahoko Matsuoka and Atsushi Manabe and Akira Kikuchi and Mamoru Ito and Atsushi Miyajima and Tatsutoshi Nakahata},
  journal={Blood},
  year={1998},
  volume={92 6},
  pages={2032-40}
}
We report here on a novel stromal cell line, AGM-S3, derived from the aorta-gonad-mesonephros (AGM) region of a 10.5 days postcoitum (dpc) mouse embryo. The AGM-S3 cells promoted production of hematopoietic progenitors and day-12 spleen colony-forming cells from Lin-c-Kit+Sca-1(+) murine primitive hematopoietic cells. They also supported for 6 weeks generation of human multipotential progenitors from cord blood CD34(+)CD38(-) primitive hematopoietic cells. Human long-term repopulating… CONTINUE READING
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