Stimulation of monovalent cation active transport by low concentrations of cardiac glycosides. Role of catecholamines.

@article{Hougen1981StimulationOM,
  title={Stimulation of monovalent cation active transport by low concentrations of cardiac glycosides. Role of catecholamines.},
  author={Thomas J. Hougen and Neville Spicer and Thomas W Smith},
  journal={The Journal of clinical investigation},
  year={1981},
  volume={68 5},
  pages={
          1207-14
        }
}
The stimulatory effect of low concentrations of ouabain on the Na-K pump in isolated guinea pig left atria was studied in vitro by assessing active transport of the K(+) analog Rb(+). Active transport of Rb(+) was stimulated 20+/-8% (SEM, P < 0.05) above control values by 3 nM ouabain, but was inhibited by concentrations >10 nM. Preincubation with the beta-adrenergic antagonist propranolol (1 muM) completely blocked stimulation of active transport of Rb(+) by 3 nM ouabain. Norepinephrine, 10 nM… CONTINUE READING
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