Stimulation of mitogen-activated protein kinase pathway in rat somatotrophs by growth hormone-releasing hormone

@article{Zeitler2000StimulationOM,
  title={Stimulation of mitogen-activated protein kinase pathway in rat somatotrophs by growth hormone-releasing hormone},
  author={Dr. Philip Zeitler and Gamini Siriwardana},
  journal={Endocrine},
  year={2000},
  volume={12},
  pages={257-264}
}
Growth hormone-releasing hormone (GHRH) is an important regulator of somatotroph development and function. However, GHRH signaling is still not completely understood. Signaling through the mitogen-activated protein kinase (MAPK) pathway has been observed in a wide variety of cell types but has not been explored as a mediator of GHRH action. In this study, we examined the phosphorylation of MAPK pathway intermediates in response to GHRH. After treatment of the GH4 rat somatotroph cell line with… CONTINUE READING
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