Stimulation of mitochondrial fatty acid oxidation by growth hormone in human fibroblasts.

@article{Leung1997StimulationOM,
  title={Stimulation of mitochondrial fatty acid oxidation by growth hormone in human fibroblasts.},
  author={K. C. Leung and Ken K Y Ho},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 12},
  pages={4208-13}
}
In vivo administration of GH induces lipolysis and lipid oxidation. However, it is not clear whether the stimulation of lipid oxidation is a direct effect of GH or is driven by increased substrate supply secondary to lipolysis. An in vitro bioassay has been established for assessing beta-oxidation of fatty acids in mitochondria, based on the measurement of conversion of tritiated palmitic acid to 5H2O by fibroblasts in culture. We have modified this assay to investigate whether GH stimulates… CONTINUE READING
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