Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4.

@article{Kanbe2002StimulationOM,
  title={Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4.},
  author={Katsuaki Kanbe and K. Takagishi and Qinghai Chen},
  journal={Arthritis and rheumatism},
  year={2002},
  volume={46 1},
  pages={
          130-7
        }
}
OBJECTIVE The chemokine family of secreted proteins regulates cellular activities through interaction with G protein-coupled chemokine receptors. The aim of this study was to analyze the role of a chemokine stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 in rheumatoid arthritis (RA) and osteoarthritis (OA) by examining their gene expression in joint cartilage and synovium and by determining the effect of their interaction on the release of matrix metalloproteases (MMPs) from… CONTINUE READING

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