Stimulation of mast cell chemotaxis by interleukin 3

  title={Stimulation of mast cell chemotaxis by interleukin 3},
  author={Nami Matsuura and Bruce R. Zetter},
  journal={The Journal of Experimental Medicine},
  pages={1421 - 1426}
PWM-activated spleen cell-conditioned medium (SCCM) and a variety of purified hematopoietic growth factors were tested for their ability to stimulate chemotaxis of mouse connective tissue mast cells (CTMC). Of the agents tested, only IL-3 and SCCM promoted mast cell chemotaxis. Neither IL-2, IL-4, GM-CSF, nor endotoxin had any significant mast cell chemotactic activity. Neutralizing antibodies to mouse IL-3 blocked greater than 90% of the chemotactic activity of SCCM, suggesting that IL-3 is… CONTINUE READING
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