Stimulation of iodide uptake by human chorionic gonadotropin in FRTL-5 cells: effects on sodium/iodide symporter gene and protein expression.

@article{Arturi2002StimulationOI,
  title={Stimulation of iodide uptake by human chorionic gonadotropin in FRTL-5 cells: effects on sodium/iodide symporter gene and protein expression.},
  author={Franco Arturi and Ivan Presta and Daniela Scarpelli and J M Bidart and Martin Schlumberger and Sebastiano Filetti and Diego Russo},
  journal={European journal of endocrinology},
  year={2002},
  volume={147 5},
  pages={655-61}
}
BACKGROUND Various clinical and experimental findings support the concept that human chorionic gonadotropin (hCG) can stimulate iodide uptake in thyroid cells. DESIGN We investigated the molecular mechanisms underlying the effects of hCG on iodide uptake, and particularly its action on the expression of Na+/I- symporter (NIS) mRNA and protein. METHODS Iodide uptake was analyzed in FTRL-5 cells by measuring (125)I concentrations in cells after a 30-min exposure to 0.1 microCi carrier-free Na… CONTINUE READING
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