Stimulation of intestinal mucosal growth with intracolonic infusion of short-chain fatty acids.

@article{Kripke1989StimulationOI,
  title={Stimulation of intestinal mucosal growth with intracolonic infusion of short-chain fatty acids.},
  author={Saul Kripke and A D Fox and Judd M Berman and R G Settle and John L. Rombeau},
  journal={JPEN. Journal of parenteral and enteral nutrition},
  year={1989},
  volume={13 2},
  pages={109-16}
}
Dietary fiber, which stimulates intestinal mucosal growth, is fermented by anaerobic bacteria in the rat hindgut to the short-chain fatty acids (SCFA) acetate, propionate, and butyrate. Butyrate is the preferred oxidative fuel of the colonocyte in vitro, and the provision of preferred intestinal fuels has been shown to stimulate mucosal proliferation in vivo. This study determined whether chronic colonic infusion of butyrate or a combination of SCFA would stimulate intestinal mucosal growth in… CONTINUE READING

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