Stimulation of interleukin-11 production from osteoblast-like cells by transforming growth factor-beta and tumor cell factors.

@article{Morinaga1997StimulationOI,
  title={Stimulation of interleukin-11 production from osteoblast-like cells by transforming growth factor-beta and tumor cell factors.},
  author={Yoshihiro Morinaga and Naoya Fujita and Kazuo Ohishi and Takashi Tsuruo},
  journal={International journal of cancer},
  year={1997},
  volume={71 3},
  pages={422-8}
}
Bone is one of the most common sites of metastasis in melanoma and breast cancer cells. Human melanoma (A375M) and human breast cancer (MDA-MB-231) cells form osteolytic bone metastasis in vivo when these tumor cells are injected into the left ventricles of BALB/c nude mice. These tumor cells promote bone resorption in the in vitro neonatal murine calvaria organ culture system by indirectly stimulating the production of a bone resorption-inducing factor (or factors) from human osteoblast-like… CONTINUE READING