Stimulation of human purine synthesis de novo by fructose infusion.

@article{Raivio1975StimulationOH,
  title={Stimulation of human purine synthesis de novo by fructose infusion.},
  author={K. Raivio and 7. A. Becker and L. Meyer and M. Greene and G. Nuki and J. Seegmiller},
  journal={Metabolism: clinical and experimental},
  year={1975},
  volume={24 7},
  pages={
          861-9
        }
}
In order to clarify the mechanism of hyperuricemia and hyperuricosuria resulting from rapid infusion of fructose in man, the effects of an intravenous infusion of 125-200 g of fructose given over 3-4 hr on the rate of purine synthesis de novo was measured in one individual with osteoarthritis and four patients with gout. The incorporation of 1-minus 14C glycine into urinary uric acid was measured, and the pool size and turnover of urate were assessed by renal excretion of simultaneously… Expand
Effect of fructose on the concentration of phosphoribosylpyrophosphate in isolated hepatocytes.
Purine metabolism during strenuous muscular exercise in man.
ENZYME DEFECT IN PRIMARY GOUT
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