Stimulation of human melanocytes by vitamin D3 possibly mediates skin pigmentation after sun exposure.

@article{Tomita1988StimulationOH,
  title={Stimulation of human melanocytes by vitamin D3 possibly mediates skin pigmentation after sun exposure.},
  author={Yoshihiko Tomita and W. Torinuki and Hachiro Tagami},
  journal={The Journal of investigative dermatology},
  year={1988},
  volume={90 6},
  pages={882-4}
}
We found an increased amount of immunoreactive tyrosinase in human melanocytes after 6-d culturing with vitamin D3 (cholecalciferol). Most of these melanocytes became more dendritic and swollen in a fashion similar to that noted in the skin after ultraviolet irradiation. However, 7-dehydrocholesterol (pro-vitamin D3) or 1 alpha,25-dihydroxy-vitamin D3 (activated vitamin D3) were found to have little effect on the same system. Because vitamin D3 is known to be photochemically converted from pro… CONTINUE READING

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