Stimulation of human IgE production by a subset of anti-CD21 monoclonal antibodies: requirement of a co-signal to modulate epsilon transcripts.

@article{Henchoz1994StimulationOH,
  title={Stimulation of human IgE production by a subset of anti-CD21 monoclonal antibodies: requirement of a co-signal to modulate epsilon transcripts.},
  author={Sybille Henchoz and Jean Gauchat and J. P. Aubry and Pierre Graber and Sibylle Pochon and Jean Yves Bonnefoy},
  journal={Immunology},
  year={1994},
  volume={81 2},
  pages={285-90}
}
CD21, the receptor for Epstein-Barr virus (EBV) and the complement receptor-2 (CR2), was recently found to interact specifically with CD23, a low-affinity receptor for IgE, and to regulate IgE production. Therefore, the effect of different anti-CD21 monoclonal antibodies (mAb) on IgE synthesis by blood mononuclear cells was investigated. One anti-CD21 mAb, BU-33, was able to increase significantly (more than threefold) interleukin-4 (IL-4)-induced IgE synthesis, whereas HB-5, OKB-7 and B2 anti… CONTINUE READING
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