Stimulation of hepatocyte growth factor production in human fibroblasts by the protein phosphatase inhibitor okadaic acid.

@article{Gohda2000StimulationOH,
  title={Stimulation of hepatocyte growth factor production in human fibroblasts by the protein phosphatase inhibitor okadaic acid.},
  author={Eiichi Gohda and Toshinori Nagao and Itaru Yamamoto},
  journal={Biochemical pharmacology},
  year={2000},
  volume={60 10},
  pages={1531-7}
}
In this study, we examined whether the production of hepatocyte growth factor (HGF) in fibroblasts is regulated by protein phosphatase(s). Inhibitors of the enzymes okadaic acid and calyculin A were used for this purpose. Both inhibitors markedly stimulated HGF production in human skin fibroblasts in a dose-dependent manner. The effects of okadaic acid and… CONTINUE READING