Stimulation of glycosaminoglycan production in cultured human retroocular fibroblasts.

@article{Korducki1992StimulationOG,
  title={Stimulation of glycosaminoglycan production in cultured human retroocular fibroblasts.},
  author={J M Korducki and Sarah J Loftus and Rebecca S. Bahn},
  journal={Investigative ophthalmology & visual science},
  year={1992},
  volume={33 6},
  pages={2037-42}
}
Histologic examination of the retroocular connective tissues in Graves' ophthalmopathy (GO) reveals lymphocytic infiltration and an accumulation of glycosaminoglycans (GAG), hydrophilic macromolecules produced locally by fibroblasts. We studied the in vitro effect on fibroblast GAG production of several cytokines and growth factors likely to be secreted by these activated lymphocytes or macrophages. Cultures were established from retroocular connective tissue, extraocular muscle perimysium, and… CONTINUE READING
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