Stimulation of glutathione depletion, ROS production and cell cycle arrest of dental pulp cells and gingival epithelial cells by HEMA.

@article{Chang2005StimulationOG,
  title={Stimulation of glutathione depletion, ROS production and cell cycle arrest of dental pulp cells and gingival epithelial cells by HEMA.},
  author={Hsiao-Hua Chang and Ming-Kuang Guo and Frederick H. Kasten and M X Chang and G Huang and Yin-Lin Wang and Ruey-Song Wang and J G Jeng},
  journal={Biomaterials},
  year={2005},
  volume={26 7},
  pages={745-53}
}
2-Hydroxy-ethyl methacrylate (HEMA) is the major component released from resin-modified glass ionomer cements and dental adhesives. Human tissues mainly affected by HEMA are oral epithelium and dental pulp. We treated human gingival epithelial S-G cells and pulp fibroblasts (HPF) with various concentrations of HEMA, to evaluate its effects on cell growth, cell cycle progression, intracellular glutathione (GSH) level and reactive oxygen species (ROS) production. HEMA-induced growth inhibition in… CONTINUE READING