Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3

@inproceedings{Ngala2014StimulationOG,
  title={Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3},
  author={Robert A. Ngala and Mohamed Zaibi and Kenneth Langlands and Claire J. Stocker and Jonathan R. S. Arch and Michael Anthony Cawthorne and Rebecca Berdeaux},
  booktitle={PeerJ},
  year={2014}
}
Kv1 channels are shaker-related potassium channels that influence insulin sensitivity. Kv1.3(-/-) mice are protected from diet-induced insulin resistance and some studies suggest that Kv1.3 inhibitors provide similar protection. However, it is unclear whether blockade of Kv1.3 in adipocytes or skeletal muscle increases glucose uptake. There is no evidence that the related channel Kv1.5 has any influence on insulin sensitivity and its expression in adipose tissue has not been reported. PAP-1 is… CONTINUE READING
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PeerJ, DOI 10.7717/peerj.614

Ngala
2014

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