Stimulation of glucose uptake by theasinensins through the AMP-activated protein kinase pathway in rat skeletal muscle cells.

@article{Qiu2014StimulationOG,
  title={Stimulation of glucose uptake by theasinensins through the AMP-activated protein kinase pathway in rat skeletal muscle cells.},
  author={Ju Qiu and Kanako Maekawa and Yuko Kitamura and Yuji Miyata and Kazunari Tanaka and Takashi Tanaka and Minoru Soga and Takanori Tsuda and Toshiro Matsui},
  journal={Biochemical pharmacology},
  year={2014},
  volume={87 2},
  pages={344-51}
}
Theasinensins, dimeric catechins, have been reported to possess anti-hyperglycemic activity, but the underlying mechanism for this activity remains unknown. In this study, the effect of theasinensins A and B on glucose uptake into rat skeletal muscle cells (L6 myotubes) was investigated. A glucose uptake study using 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxyglucose (2-NBDG) indicated that both theasinensins A and B stimulated glucose uptake in a concentration-dependent manner and… CONTINUE READING