Stimulation of glucose and amino acid transport and activation of the insulin signaling pathways by insulin lispro in L6 skeletal muscle cells.

@article{Somwar1998StimulationOG,
  title={Stimulation of glucose and amino acid transport and activation of the insulin signaling pathways by insulin lispro in L6 skeletal muscle cells.},
  author={Romel Somwar and G. J. Sweeney and Toolsie Ramlal and Amira Klip},
  journal={Clinical therapeutics},
  year={1998},
  volume={20 1},
  pages={125-40}
}
The monomeric insulin analogue insulin lispro (Lys B28, Pro B29) is a rapid-acting insulin with a shorter duration of activity than human regular insulin. This compound has the advantage of reducing early postprandial hyperglycemia and the accompanying late hypoglycemia, thereby improving overall blood glucose control. To date, all published studies of the functional properties of insulin lispro have been conducted in whole animals. This study aimed to characterize the cellular actions of… CONTINUE READING