Stimulation of gene induction and cell growth by the Ras effector Rlf.

@article{Wolthuis1997StimulationOG,
  title={Stimulation of gene induction and cell growth by the Ras effector Rlf.},
  author={Rob M. F. Wolthuis and Nancy D de Ruiter and Robbert H. Cool and Johannes L Bos},
  journal={The EMBO journal},
  year={1997},
  volume={16 22},
  pages={
          6748-61
        }
}
Rlf is a ubiquitously expressed distinct relative of RalGDS that interacts with active Ras in vitro. We now demonstrate that Rlf, when co-expressed with Ras mutants, associates in vivo with RasV12 and the effector-domain mutant RasV12G37, but not with RasV12E38 or RasV12C40. Rlf exhibits guanine nucleotide exchange activity towards the small GTPase Ral and, importantly, Rlf-induced Ral activation is stimulated by active Ras. In addition, RasV12 and RasV12G37 synergize with Rlf in the… CONTINUE READING

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with structural and functional homology with the gene family of exchange factors for Ral

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