Stimulation of gastric acid secretion by cAMP in a novel alpha-toxin-permeabilized gland model.

@article{Yao1996StimulationOG,
  title={Stimulation of gastric acid secretion by cAMP in a novel alpha-toxin-permeabilized gland model.},
  author={Xuebiao Yao and Sherif M. Karam and Marlon Ramilo and Qinfen Rong and Alexandre Thibodeau and John G. Forte},
  journal={The American journal of physiology},
  year={1996},
  volume={271 1 Pt 1},
  pages={C61-73}
}
It is generally believed that histamine-stimulated gastric acid secretion involves a transient elevation of intracellular Ca2+ and the adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase (PKA) cascade through phosphorylation, whose actions ultimately effect the fusion of H(+)-K(+)-adenosinetriphosphatase (ATPase)-containing vesicles to the apical plasma membrane of parietal cells. To dissect the signaling events underlying gastric acid secretion, we have developed a… CONTINUE READING