Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor.

@article{Frazier1996StimulationOF,
  title={Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor.},
  author={Kendall S Frazier and Shant{\'e} P Williams and Devashish Kothapalli and Helene Klapper and Gary R. Grotendorst},
  journal={The Journal of investigative dermatology},
  year={1996},
  volume={107 3},
  pages={404-11}
}
Connective tissue growth factor (CTGF) is a 36-to 38-kDa peptide that is selectively induced by transforming growth factor-beta (TGF-beta) in fibroblastic cell types. We compared the biologic activities of CTGF with TGF-beta on fibroblasts in culture and in animal models of fibroplasia. CTGF was active as a mitogen in monolayer cultures of normal rat kidney fibroblasts. CTGF did not stimulate anchorage-independent growth of NRK fibroblasts, however, or inhibit the growth of mink lung epithelial… CONTINUE READING
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