Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent.

@article{Swarthout2001StimulationOE,
  title={Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent.},
  author={J. Todd Swarthout and Teresa Ann Doggett and J L Lemker and Nicola C Partridge},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 10},
  pages={
          7586-92
        }
}
Parathyroid hormone (PTH) is known to have both catabolic and anabolic effects on bone. The dual functionality of PTH may stem from its ability to activate two signal transduction mechanisms: adenylate cyclase and phospholipase C. Here, we demonstrate that continuous treatment of UMR 106-01 and primary osteoblasts with PTH peptides, which selectively activate protein kinase C, results in significant increases in DNA synthesis. Given that ERKs are involved in cellular proliferation, we examined… CONTINUE READING

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