Stimulation of epithelial cell growth by the neuropeptide substance P.

@article{Reid1993StimulationOE,
  title={Stimulation of epithelial cell growth by the neuropeptide substance P.},
  author={Ted W. Reid and Christopher John Murphy and Christine K Iwahashi and Barbara A. Foster and Mark J. Mannis},
  journal={Journal of cellular biochemistry},
  year={1993},
  volume={52 4},
  pages={476-85}
}
The neuropeptide substance P (SP) was found to stimulate DNA synthesis and cell growth for epithelial cells (cornea and lens) in a serum-free environment. The length of treatment time was shown to be important since longer times shifted the dose-response curve to the left. In short-term DNA synthesis studies (40 h) the stimulation with SP (or synergism with insulin) was not apparent until close to 10 microM, however, when DNA synthesis assays were carried out over a long period of time (5 days… CONTINUE READING