Stimulation of enveloped virus infection by beta-amyloid fibrils.

  title={Stimulation of enveloped virus infection by beta-amyloid fibrils.},
  author={Woj M Wojtowicz and Michael Farzan and John L. Joyal and Kara Carter and Gregory J. Babcock and David I. Israel and Joseph Sodroski and Tajib A. Mirzabekov},
  journal={The Journal of biological chemistry},
  volume={277 38},
Alzheimer's disease is characterized by deposition of beta-amyloid peptide (Abeta) into plaques in the brain, leading to neuronal toxicity and dementia. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system can also cause a dementia, and amyloid deposition in the central nervous system is significantly higher in HIV-1-infected individuals compared with uninfected controls. Here we report that Abeta fibrils stimulated, by 5-20-fold, infection of target cells… CONTINUE READING


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