Stimulation of endothelial nitric oxide production by homocyst(e)ine.

@article{Upchurch1997StimulationOE,
  title={Stimulation of endothelial nitric oxide production by homocyst(e)ine.},
  author={Gilbert R. Upchurch and Gary Welch and Attila J. Fabian and Alessio Pigazzi and John F. Keaney and Joseph Loscalzo},
  journal={Atherosclerosis},
  year={1997},
  volume={132 2},
  pages={177-85}
}
Hyperhomocyst(e)inemia, characterized by accelerated atherosclerosis, is believed to induce endothelial cell injury and promote atherothrombosis by supporting the generation of hydrogen peroxide. Earlier observations in our laboratory demonstrated that in vitro nitrosation of homocyst(e)ine (HCY) prevents the generation of hydrogen peroxide. We, therefore, hypothesized that stimulating the production of nitric oxide (NO) by endothelial cells would detoxify HCY by forming the corresponding S… CONTINUE READING