Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study.

@article{Yoshikawa2009StimulationOE,
  title={Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study.},
  author={Hideki Yoshikawa and Kiyoko Yoshioka and Takanobu Nakase and Kazuyuki Itoh},
  journal={Clinical orthopaedics and related research},
  year={2009},
  volume={467 12},
  pages={3087-95}
}
The small GTPase Rho and Rho-associated protein kinase (Rho kinase, ROCK) signal participates in a variety of biological functions including vascular contraction, tumor invasion, and penile erection. Evidence also suggests Rho-ROCK is involved in signaling for mesenchymal cellular differentiation. However, whether it is involved in osteoblastic differentiation is unknown. We therefore asked whether Rho-ROCK signaling participates in recombinant human bone morphogenetic protein (rhBMP-2)-induced… CONTINUE READING