Stimulation of colorectal cancer cell line growth by ET-1 and its inhibition by ET(A) antagonists.

@article{Ali2000StimulationOC,
  title={Stimulation of colorectal cancer cell line growth by ET-1 and its inhibition by ET(A) antagonists.},
  author={Hind Ali and Marilena Loizidou and Michael Dashwood and Felicity J. Savage and Charles Sheard and Irving Taylor},
  journal={Gut},
  year={2000},
  volume={47 5},
  pages={685-8}
}
BACKGROUND The vasoactive peptide endothelin 1 (ET-1) acts via two receptors, endothelin receptors A (ET(A)) and B (ET(B)). ET-1 is overexpressed by human cancers in vivo and in vitro and may be mitogenic for cancer cells. METHOD To elucidate if ET-1 is a growth regulator the following were investigated in human colorectal cancer cell lines (LIM1215 and HT29): ET-1 production by ELISA; ET receptor expression using radioligand autoradiographic techniques; and responsiveness to ET-1, and to ET… CONTINUE READING

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