Stimulation of colorectal cancer cell line growth by ET-1 and its inhibition by ET(A) antagonists.

  title={Stimulation of colorectal cancer cell line growth by ET-1 and its inhibition by ET(A) antagonists.},
  author={Hind Ali and Marilena Loizidou and Michael Dashwood and Felicity J. Savage and Charles Sheard and Irving Taylor},
  volume={47 5},
BACKGROUND The vasoactive peptide endothelin 1 (ET-1) acts via two receptors, endothelin receptors A (ET(A)) and B (ET(B)). ET-1 is overexpressed by human cancers in vivo and in vitro and may be mitogenic for cancer cells. METHOD To elucidate if ET-1 is a growth regulator the following were investigated in human colorectal cancer cell lines (LIM1215 and HT29): ET-1 production by ELISA; ET receptor expression using radioligand autoradiographic techniques; and responsiveness to ET-1, and to ET… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 34 references

Expression of ET - 1 and ETA receptor in ovarian carcinoma : evidence for an autocrine role in tumour growth

  • A Bagnato, D Salani, V DiCastro
  • Cancer Res
  • 1999

Expression of endothelin - 1 in 98 patients with colorectal cancer

  • E Asham, M Loizidou, S Lakhani
  • Eur J Surg Oncol
  • 1998

derived cells : implications for regulation of endothelin bioactivity and bioavailability in prostatic hyperplasia

  • MK Saville, A Graham, K Malarkey
  • 1998

Production and secretion of endothelin - 1 in colorectal cancer

  • E Asham, A Shankar, M Loizidou
  • Br J Surg
  • 1997

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