Stimulation of collagen biosynthesis by topically applied vitamin C.

  title={Stimulation of collagen biosynthesis by topically applied vitamin C.},
  author={Betty V. Nusgens and Philippe Humbert and Andr{\'e} Rougier and Alain Richard and Ch. M. Lapi{\`e}re},
  journal={European journal of dermatology : EJD},
  volume={12 4},
In the dermis, vitamin C is required for the formation of hydroxyprolyl residues to form stable triple-helical collagen molecules, and hydroxylysyl residues operating in crosslinks synthesis. In fibroblasts culture, vitamin C is also known to stabilize the collagen messenger RNAs (m-RNA) and increase procollagen synthesis. The activity in the dermis of vitamin C topically applied on normal human skin is demonstrated in the present study by observing an increased steady-state level of the m-RNA… 
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