Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation.

@article{Wei2010StimulationOC,
  title={Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation.},
  author={Lei Wei and Katsuaki Kanbe and Mark Lee and Xiao-chun Wei and Ming Pei and Xiaojuan Sun and Richard M. Terek and Qian Chen},
  journal={Developmental biology},
  year={2010},
  volume={341 1},
  pages={236-45}
}
During endochondral bone formation, chondrocytes undergo differentiation toward hypertrophy before they are replaced by bone and bone marrow. In this study, we found that a G-protein coupled receptor CXCR4 is predominantly expressed in hypertrophic chondrocytes, while its ligand, chemokine stromal cell-derived factor 1 (SDF-1) is expressed in the bone marrow adjacent to hypertrophic chondrocytes. Thus, they are expressed in a complementary pattern in the chondro-osseous junction of the growth… CONTINUE READING