Stimulation of chemically induced rectal carcinogenesis by chronic ethanol ingestion.

@article{Seitz1985StimulationOC,
  title={Stimulation of chemically induced rectal carcinogenesis by chronic ethanol ingestion.},
  author={Helmut Karl Seitz and Peter Czygan and Ulrich A. Simanowski and Ruediger Waldherr and Satsie Veith and Richard Raedsch and Burkhard Kommerell},
  journal={Alcohol and alcoholism},
  year={1985},
  volume={20 4},
  pages={427-33}
}
The effect of chronic ethanol administration on 1, 2-dimethylhydrazine-induced rectal carcinogenesis was investigated in 32 paired male Sprague-Dawley rats fed a nutritionally-adequate liquid diet containing 36% of the total calories as either ethanol or isocaloric carbohydrates. Chronic ethanol ingestion increased the total number of rectal tumors significantly (17 vs 6; P less than 0.02), whereas no cocarcinogenic effect of ethanol was observed in other parts of the intestine. Alcohol did not… CONTINUE READING