Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils

Abstract

Kazinol B, a natural isoprenylated flavan, stimulated the [Ca2+]i elevation in the presence or absence of Ca2+ in the medium. Treatment with chymotrypsin or phorbol 12-myristate 13-acetate to shedding of l-selectin had no effect on subsequent kazinol B-induced Ca2+ response. Upon initial cyclopiazonic acid (CPA) treatment in the absence of external Ca2… (More)
DOI: 10.1007/s00210-004-0997-3

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