Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils


Kazinol B, a natural isoprenylated flavan, stimulated the [Ca2+]i elevation in the presence or absence of Ca2+ in the medium. Treatment with chymotrypsin or phorbol 12-myristate 13-acetate to shedding of l-selectin had no effect on subsequent kazinol B-induced Ca2+ response. Upon initial cyclopiazonic acid (CPA) treatment in the absence of external Ca2… (More)
DOI: 10.1007/s00210-004-0997-3


9 Figures and Tables