Stimulation of cell proliferation and expression of matrixmetalloproteinase-1 and interluekin-8 genes in dermal fibroblasts by copper.

@article{Philips2010StimulationOC,
  title={Stimulation of cell proliferation and expression of matrixmetalloproteinase-1 and interluekin-8 genes in dermal fibroblasts by copper.},
  author={Neena Philips and Hyeondo Luke Hwang and Sagar Chauhan and Donna Leonardi and Salvador Gonz{\'a}lez},
  journal={Connective tissue research},
  year={2010},
  volume={51 3},
  pages={224-9}
}
Copper is essential to wound healing as well as a widespread environmental pollutant, with skin aging potential. Wound healing and skin aging are facilitated by matrixmetalloproteinases (MMP), which remodel the extracellular matrix, and interleukin-8 (IL-8), linked with copper. This research investigated the mechanism to copper's role in wound healing or skin aging by regulation of MMP-1 and IL-8 genes. It examined the dose-responsive effects of copper on MMP-1, -2, and -9 activities; MMP-1 and… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
14 Extracted Citations
34 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 14 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 34 references

The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway

  • C. Di Serio, L. Doria, +7 authors F. Tarantini
  • Cancer Lett., 267,
  • 2008
2 Excerpts

Similar Papers

Loading similar papers…