Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn.

Leslie A. Cary; Julia Y F Chang; Jun-Lin Guan

@article{Cary1996StimulationOC, title={Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn.}, author={Leslie A. Cary and Julia Y F Chang and Jun-Lin Guan}, journal={Journal of cell science}, year={1996}, volume={109 ( Pt 7)}, pages={1787-94} }

Cellular interactions with the extracellular matrix proteins play important roles in a variety of biological processes. Recent studies suggest that integrin-mediated cell-matrix interaction can transduce biochemical signals across the plasma membrane to regulate cellular functions such as proliferation, differentiation and migration. These studies have implicated a critical role of focal adhesion kinase (FAK) in integrin-mediated signal transduction pathways. We report here that overexpression… CONTINUE READING

Guan, J.-L., J. E. Trevithick, R. O. Hynes
Cell Regul. 2, 951-964.
1991

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn.

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References

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Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblasts.

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

Focal adhesion kinase: an integrin-linked protein tyrosine kinase.

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein

Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumor cells

Fourier analysis of cell motility: correlation of motility with metastatic potential.

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