Corpus ID: 46338920

Stimulation of capillary tube polymorph migration: an indirect glucocorticoid effect on microtubular function.

  title={Stimulation of capillary tube polymorph migration: an indirect glucocorticoid effect on microtubular function.},
  author={R. Stevenson and A. Gray and N. Lucie},
  journal={Clinical and experimental immunology},
  volume={33 3},
Polymorph migration stimulator (PMS) is a peptide factor produced by an in vitro reaction between glucocorticoids and human mononuclear phagocytes. This study was undertaken to determine the significance of the stimulatory effect of PMS on the capillary tube migration of human polymorphs. Colchicine, vinblastine and Nocodazole, all of which inhibit microtubular assembly, are shown to stimulate migration. Conversely, deuterium oxide which stabilizes microtubules inhibits migration. Increased… Expand
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