Stimulation of calcium-sodium exchange in dog red blood cells by hemolysis and resealing.

@article{Parker1988StimulationOC,
  title={Stimulation of calcium-sodium exchange in dog red blood cells by hemolysis and resealing.},
  author={J. Carlyle Parker},
  journal={Biochimica et biophysica acta},
  year={1988},
  volume={943 3},
  pages={
          463-70
        }
}
Osmotic hemolysis and resealing greatly increase calcium influx in dog red blood cells. The resealed ghosts show a saturable calcium entry pathway with complex kinetics. As expected for a calcium-sodium exchanger, calcium uptake is stimulated by internal sodium and inhibited by external sodium. Compared to fresh, intact red cells the resealed ghost calcium-sodium exchanger is less responsive to quinidine and to alterations in medium tonicity. The differences in calcium uptake rate among cells… CONTINUE READING
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