Corpus ID: 13187758

Stimulation of calcium mobilization but not proliferation by bombesin and tachykinin neuropeptides in human small cell lung cancer cells.

@article{Takuwa1990StimulationOC,
  title={Stimulation of calcium mobilization but not proliferation by bombesin and tachykinin neuropeptides in human small cell lung cancer cells.},
  author={N. Takuwa and Y. Takuwa and Y. Ohue and H. Mukai and K. Endoh and K. Yamashita and M. Kumada and E. Munekata},
  journal={Cancer research},
  year={1990},
  volume={50 2},
  pages={
          240-4
        }
}
The tachykinin family of neuropeptides, including substance P and neurokinins A and B, induce a transient increase in intracellular free calcium concentration in human small cell lung carcinoma (SCLC) cells, as measured with a calcium indicator fura-2. The effects are dose dependent and even greater than that of bombesin at equimolar concentrations in these cells. The tachykinins, like bombesin, induce calcium mobilization mainly from intracellular store(s). None of the peptides, however, shows… Expand
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TLDR
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TLDR
It is concluded that growth of SCLC cells is not dependent on bombsin under all in vitro culture conditions because bombesin failed to stimulate growth in liquid cultures and the growth inhibition caused byBombesin antagonists was probably not mediated by the bombes in receptor. Expand
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TLDR
It is suggested that bombesin congeners can act on some small cell lung cancer cell lines by a pathway utilizing increased [Ca2+]i. Expand
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TLDR
The activation of phospholipase C in SCLC by bombesin congeners is demonstrated, and a regulatory role for protein kinase C, a cholera-toxin substrate, and perhaps a pertussis-t toxin substrate are suggested in the response of SclC tobombesin. Expand
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TLDR
Bombesin and litorin may provide useful model peptides for studies on the mechanism(s) by which extracellular ligands control cell proliferation and vasopressin, phorbol esters, or cAMP increasing agents fail to enhance the maximal level of DNA synthesis induced by bombesin. Expand
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TLDR
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TLDR
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TLDR
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