• Biology, Medicine
  • Published in Journal of cell science 1995

Stimulation of calcium influx by platelet activating factor in Dictyostelium.

  title={Stimulation of calcium influx by platelet activating factor in Dictyostelium.},
  author={R Schaloske and C Sordano and Salvatore Bozzaro and Dieter Malchow},
  journal={Journal of cell science},
  volume={108 ( Pt 4)},
Platelet activating factor (PAF) induces Ca2+ influx in Dictyostelium discoideum. In this investigation we used this activity to analyze the mechanism of PAF action. We found that PAF activity was confined to the period of spike-shaped oscillations and suggest that the role of PAF is to augment cAMP relay. PAF seems to act only a few times during this time period of two hours, since Ca2+ entry adapted to a subsequent stimulus for about 30 minutes. PAF showed a reduced response in the G protein… CONTINUE READING